Education and Academic Experience
2021- School of Biopharmacy, China Pharmaceutical University
2017-2020 School of Medicine & Holistic Integrative Medicine, Nanjing University of Chinese Medicine
2011-2017 Ph.D., School of Life Sciences, Nanjing University
2007-2011 B.S., School of Life Sciences, Nanjing University
Research Summary
1. Target identification and mechanism of action investigation of anti-cancer natural products;
2. New therapeutic targets discovery for cancer and Alzheimer’s’ disease;
Projects and Honors
1. Study on expression regulation mechanism of TREM2 in microglia with amodiaquine as a probe in AD, National Natural Science Foundation of China, approval No. 81903588;
2. Novel mechanism investigation of TREM2 expression regulation in microglia with amodiaquine as a molecular probe in AD, Natural Science Foundation of Jiangsu Province, approval No. BK20190799;
Email：
xchen@cpu.edu.cn
Publications：
1. Chen X, Wang Y, Tian J, Shao Y, Zhu B, Wang J, Hua Z. Quantitative Chemical Proteomics Reveals Resveratrol Inhibition of A549 Cell Migration Through Binding Multiple Targets to Regulate Cytoskeletal Remodeling and Suppress EMT. Frontiers in pharmacology. 2021 Mar 26;12:368.
2. Chen X, Wang Y, Ma N, Tian J, Shao Y, Zhu B, Wong YK, Liang Z, Zou C, Wang J. Target identification of natural medicine with chemical proteomics approach: probe synthesis, target fishing and protein identification. Signal Transduction and Targeted Therapy. 2020 May 21;5(1):1-3.
3. Chen X, Li W, Xu C, Wang J, Zhu B, Huang Q, Chen D, Sheng J, Zou Y, Lee YM, Tan R. Comparative profiling of analog targets: a case study on resveratrol for mouse melanoma metastasis suppression. Theranostics. 2018;8(13):3504.
4. Chen X, Wang J, Fu Z, Zhu B, Wang J, Guan S, Hua Z. Curcumin activates DNA repair pathway in bone marrow to improve carboplatin-induced myelosuppression. Scientific reports. 2017 Dec 18;7(1):1-1.
5. Chen X, Zhang J, Yuan L, Lay Y, Wong YK, Lim TK, Ong CS, Lin Q, Wang J, Hua Z. Andrographolide suppresses MV4-11 cell proliferation through the inhibition of FLT3 signaling, fatty acid synthesis and cellular iron uptake. Molecules. 2017 Sep;22(9):1444.
6. Chen X, Wong YK, Lim TK, Lim WH, Lin Q, Wang J, Hua Z. Artesunate activates the intrinsic apoptosis of HCT116 cells through the suppression of fatty acid synthesis and the NF-κB pathway. Molecules. 2017 Aug;22(8):1272.
7. Chen X, Wong YK, Wang J, Zhang J, Lee YM, Shen HM, Lin Q, Hua ZC. Target identification with quantitative activity based protein profiling (ABPP). Proteomics. 2017 Feb;17(3-4):1600212.
8. Fu Z, Chen X, Guan S, Yan Y, Lin H, Hua ZC. Curcumin inhibits angiogenesis and improves defective hematopoiesis induced by tumor-derived VEGF in tumor model through modulating VEGF-VEGFR2 signaling pathway. Oncotarget. 2015 Aug 14;6(23):19469.
